8 mimics of depression in medically ill patients

Category
Percentage
of our
sample
Distinguishing features Suggested interventions
Depressed 29% -Emotional symptoms: Depressed mood, anhedonia
-Cognitive symptoms: concentration problems, indecisiveness, negative thoughts, irrational guilt
-Physical symptoms: changes in sleep, appetite, energy
Initiate psychotherapy with or without antidepressants

Demoralized - difficulty in coping with medical illness

23% Close temporal association with illness.
Few neurovegetative symptoms.
Able to maintain future orientation/hope
-Compassion, recognition, and normalization.
-illness-specific supports (groups, social work, chaplaincy).
-Physical therapy (eg, PT/OT).
Disaffiliated - grief 3% Few neurovegetative symptoms.
Able to maintain future orientation/hope.
Improvement typical as time since loss increases

-Supportive therapy

-Spiritual support

“Difficult” - patients have a breakdown in the therapeutic alliance with their treatment team 15% Mood changes often intense, immediate, and reactive to situation.
Frequent breakdowns in communication with care team.
Care team more distressed by patient’s symptoms than the patient

-Frequent communication among care team members

-Multidisciplinary care conferences to clarify salient issues

-Provide patients with consistent information and expectations

Delusional 2% Suspicious about care
team/procedures. Seems
frightened or scans the
room. On antipsychotics
at admission. Slowly
developing symptoms over
several days after home
medications are held

Acquire collateral history (an
assigned community case
manager or social worker
can be an important source).
Establish a plan for administering
psychotropics in chronically
mentally ill patients; consider
IM or orally disintegrating
formulations

Dulled - cognitive deficits 2% Baseline impairments in
memory and/or independent
functioning

Acquire collateral history. Perform
a safety assessment of home
environment with attention to
need for additional supports

Drugged - substance use or withdrawal 12% Acute presentation closely
mimicking mood, anxiety,
or psychotic disorders.
Emotional symptoms
present when intoxicated or
withdrawing and resolved
during sobriety

Implement safety interventions to
prevent self-harm or aggression
during acute phase. Support
and monitor withdrawal as
indicated. Reassess mood state
and symptoms once the patient
is sober. Refer for chemical
dependency evaluation

Delirious 11% Disoriented and inattentive.
Onset over hours to
days. Waxing and waning
throughout the day. Possible
hallucinations (often visual
or tactile)

Identify and correct underlying
medical cause(s). Restore the
patient’s sleep-wake cycle.
Provide frequent reorientation and
reassurance