| Substance abuse |
Very high |
Moderate |
| Family history |
Almost uniform |
Sometimes |
| Seasonality |
Common |
Occasional |
| First episode <25 years |
Very common |
Sometimes |
| Postpartum illness |
Very common |
Sometimes |
| Psychotic features <35 years |
Highly predictive |
Uncommon |
| Atypical features |
Common |
Occasional |
| Rapid on/off pattern |
Typical |
Unusual |
| Recurrent major depressive episodes (>3) |
Common |
Unusual |
| Antidepressant-induced mania or hypomania |
Predictive |
Uncommon |
| Brief major depressive episodes (avg <3 months) |
Suggestive |
Unusual (episode duration usually >3 months) |
| Wearing off of antidepressant efficacy |
Suggestive |
Uncommon |
| Mixed depression (presence of hypomanic features within the depressive episode) |
Predictive |
Rare |